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Mind and brain in Rett disorder
A M Kerr1, P Belichenko, T Woodcock
1Department of Psychological Medicine, University of Glasgow, Gartnavel Royal Hospital, 1055 Great Western Road, G21 0XH, Glasgow, UK. amk5m@clinmed.gla.ac.uk
Abstract:
Development and retention of speech is reported in 265 people with Rett syndrome: 30% (80) never gained real words, 55% (145) gained real words and lost them, 15%(40) retained some words and 6% of the total (16/265) continued to use phrases appropriately. Morphological studies of the cytoarchitecture of the speech areas in 14 cases indicate the existence of interhemispheric differences which form part of the infrastructure for speech processing. Ten adults with Rett syndrome and with meaningful speech are compared to age matched adults without speech. The profile of mind and strategies for coping with its problems are described by a family. Although the range in severity is wide the mental profile is remarkably consistent across the severity range with regard to both positive and negative aspects.
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