Ion-channel assay technologies: quo vadis?

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Updated: Oct 3, 2026

Capturing the Interaction Kinetics of an Ion Channel Protein with Small Molecules by the Bio-layer Interferometry Assay
10:41

Capturing the Interaction Kinetics of an Ion Channel Protein with Small Molecules by the Bio-layer Interferometry Assay

Published on: March 7, 2018

Jia Xu1, Xiaobo Wang, Brooks Ensign

  • 1AVIVA Biosciences Corporation, 11568 Sorrento Valley Road, Suite 9, 92121, San Diego, CA, USA

Drug Discovery Today
|December 12, 2001
PubMed

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Patch Clamp01:18

Patch Clamp

Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...