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Blood lipids and first-ever ischemic stroke/transient ischemic attack in the Bezafibrate Infarction Prevention (BIP)

D Tanne1, N Koren-Morag, E Graff

  • 1Department of Neurology, Stroke Unit, Chaim Sheba Medical Center, Tel Hashomer, Israel. tanne@post.tau.ac.il

Circulation
|December 12, 2001
PubMed

Insights

High triglycerides increase ischemic stroke risk, while higher HDL cholesterol protects patients with coronary heart disease. These blood lipids are modifiable stroke risk factors.

Area of Science:

  • Cardiovascular Medicine
  • Neurology
  • Lipid Metabolism

Background:

  • Unclear links between blood lipids and stroke risk.
  • Lipid-modifying agents show stroke risk reduction in coronary heart disease (CHD) patients.

Purpose of the Study:

  • Investigate the association between blood lipids and ischemic stroke/transient ischemic attack (TIA) risk in patients with CHD.

Main Methods:

  • Followed 11,177 patients with CHD without prior stroke/TIA.
  • Assessed baseline medical history and blood lipids.
  • Analyzed incidence of ischemic stroke/TIA over 6-8 years using logistic regression.

Main Results:

  • Higher triglycerides (>200 mg/dL) correlated with increased ischemic stroke/TIA risk (OR 1.27).
  • Lower high-density lipoprotein (HDL) cholesterol and %HDL were associated with higher risk.
  • High triglycerides posed a risk across various patient subgroups.

Conclusions:

  • Elevated triglycerides are an independent risk factor for ischemic stroke/TIA.
  • Higher %HDL is an independent protective factor against stroke/TIA in CHD patients.
  • Blood lipids, particularly triglycerides, are important modifiable stroke risk factors.
Abstract

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