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Related Experiment Videos

Apolipoprotein D mRNA expression is elevated in PDAPP transgenic mice.

E A Thomas1, L N Sautkulis, J R Criado

  • 1Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, USA.

Journal of Neurochemistry
|December 12, 2001
PubMed
Summary
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Apolipoprotein D (apoD) increases in aging brains, with higher levels in Alzheimer

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Pathology

Background:

  • Apolipoprotein D (apoD) expression is elevated in CNS pathology.
  • Its role in Alzheimer's disease neuropathology requires investigation.

Purpose of the Study:

  • To investigate the role of apoD in Alzheimer's disease (AD) neuropathology.
  • To measure apoD mRNA expression in PDAPP transgenic mice.

Main Methods:

  • In situ hybridization was used to analyze apoD mRNA expression.
  • PDAPP transgenic mice and age-matched controls were studied at young (6 months) and aged (26 months) stages.

Main Results:

  • Aged PDAPP mice showed increased apoD mRNA in white matter tracts (hippocampal fimbria, corpus callosum) compared to aged controls.

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  • Young PDAPP mice did not show significant increases.
  • Aged control mice also exhibited increased apoD expression in white matter compared to young controls.

    • Conclusions:

    • Increased apoD expression is a feature of normal brain aging.
    • Elevated apoD in PDAPP mice may indicate a glial cell compensatory response to beta-amyloid deposition in Alzheimer's disease.