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Related Experiment Videos

Botulinum toxin type A in primary palmar hyperhidrosis: randomized, single-blind, two-dose study.

D Saadia1, A Voustianiouk, A K Wang

  • 1Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA.

Neurology
|December 12, 2001
PubMed
Summary

Intradermal botulinum toxin injections effectively reduce palmar hyperhidrosis for months. While generally safe, higher doses may temporarily decrease hand pinch strength, though grip strength remains unaffected.

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Area of Science:

  • Neurology
  • Dermatology
  • Pharmacology

Background:

  • Primary palmar hyperhidrosis involves excessive hand sweating due to heightened sympathetic nerve activity.
  • Clinical evidence suggests botulinum toxin injections are a viable treatment for palmar hyperhidrosis.

Purpose of the Study:

  • To evaluate the efficacy of intradermal botulinum toxin for hyperhidrosis reduction.
  • To identify the optimal botulinum toxin dosage for treatment.
  • To assess the impact of botulinum toxin on hand muscle strength.

Main Methods:

  • A prospective, randomized, single-blind trial involving 24 patients with severe palmar hyperhidrosis.
  • Participants received either 50 U or 100 U of botulinum toxin type A (Botox) intradermally in 20 sites per palm.

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  • Sweating reduction was assessed using the iodine starch test, and hand muscle strength was measured.

    • Main Results:

    • Both 50 U and 100 U doses significantly reduced palmar sweating within one month, with effects lasting up to six months in most patients.
    • Handgrip strength was unaffected by either dose.
    • Finger pinch strength decreased two weeks post-injection (23% with 50 U, 40% with 100 U), with partial recovery by six months.

    Conclusions:

    • Intradermal botulinum toxin type A (50 U and 100 U) effectively decreases sweating in primary palmar hyperhidrosis patients for at least two to six months.
    • A transient decrease in intrinsic hand muscle pinch strength was observed, particularly with the higher dose.