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Updated: Aug 15, 2026

Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease
Published on: June 17, 2013
Motor perseveration is an early sign of Parkinson's disease
D Stoffers1, H W Berendse, J B Deijen
1Department of Neurology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands. d.stoffers@vumc.nl
Abstract:
Perseveration in the generation of random motor behavior was examined by means of the Vienna perseverance task in groups of de novo (n = 18) and treated (n = 18) patients with early PD, and in control subjects (n = 18). In comparison with control subjects, both the de novo and treated patients with PD were relatively unable to generate random motor sequences, indicating a decreased ability to switch cortical behavioral programs in PD. An impairment of random motor generation appears to be a very early feature of PD.
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