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Mannitol bolus preferentially shrinks non-infarcted brain in patients with ischemic stroke

T O Videen1, A R Zazulia, E M Manno

  • 1Department of Neurology and Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA. tom@npg.wustl.edu

Neurology
|December 12, 2001
PubMed

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An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...