Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

CD markers in pituitary adenomas.

W Saeger1

  • 1Institute of Pathology of the Marienkrankenhaus Hamburg. WolfgangSaeger.HH@t-online. de

Endocrine Pathology
|December 12, 2001
PubMed
Summary

The expression of CD markers varies significantly across different pituitary adenoma types, suggesting potential immune system interactions. Noninvasive adenomas showed more frequent CD marker expression than invasive ones.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Novel AIP mutation in exon 6 causing acromegaly in a German family.

Journal of endocrinological investigation·2023
Same author

Typing of inflammatory lesions of the pituitary.

Pituitary·2021
Same author

Adrenal cancer: relevance of different grading systems and subtypes.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·2021
Same author

A standardised diagnostic approach to pituitary neuroendocrine tumours (PitNETs): a European Pituitary Pathology Group (EPPG) proposal.

Virchows Archiv : an international journal of pathology·2019
Same author

[Tumors of the adrenal glands : Update].

Der Pathologe·2019
Same author

[Ectopic tissue].

Der Pathologe·2018

Area of Science:

  • Endocrinology
  • Immunology
  • Oncology

Background:

  • CD marker expression in normal pituitary cells is known, but not extensively studied in pituitary adenomas.
  • Pituitary adenomas are common tumors affecting hormone regulation.

Purpose of the Study:

  • To investigate the expression patterns of various CD markers in different types of pituitary adenomas.
  • To determine if CD marker expression correlates with adenoma type or invasiveness.

Main Methods:

  • Immunohistochemical analysis of 65 pituitary adenomas for CD 3, CD 8, CD 15, CD 20, CD 30, CD 43, CD 45RO, CD 45 R, CD 79 alpha, and VS-38c.
  • Correlation of marker expression with specific adenoma subtypes (GH, prolactin, ACTH, TSH, gonadotroph, etc.).

Main Results:

  • Significant variation in CD marker expression was observed across different pituitary adenoma types.
  • CD 3, CD 20, and CD 45 RO were frequently expressed across multiple adenoma subtypes.
  • Noninvasive adenomas demonstrated a higher frequency of CD marker expression compared to invasive adenomas.

Conclusions:

  • The diverse CD marker expression profiles in pituitary adenomas suggest complex local immune interactions.
  • Further research is needed to elucidate the functional significance of these CD markers in pituitary tumorigenesis.

Related Experiment Videos