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Published on: May 15, 2019
Mechanism of action of thalidomide and 3-aminothalidomide in multiple myeloma
R J D'Amato1, S Lentzsch, K C Anderson
1Enders 1006, Children's Hospital, 300 Longwood Ave., Boston, MA 02115, USA.
Abstract:
We have explored the mechanism of the antiangiogenic effects of thalidomide by structure-activity studies. These investigations revealed that angiogenesis inhibition correlates with teratogenicity but not with tumor necrosis factor-alpha (TFA-alpha) inhibition. Additionally, one analog of thalidomide, 3-aminothalidomide, exhibited an unusual capacity to directly inhibit myeloma cell proliferation. This activity did not correlate with TNF-alpha inhibition. Thus 3-aminothalidomide was found to inhibit multiple myeloma through effects on both the tumor and vascular compartment. The effects of an inhibitor of both the tumor and vascular compartments of a tumor on tumor growth may be synergistic.
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