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Deep lamellar keratoplasty.

F Trimarchi1, E Poppi, C Klersy

  • 1Policlinico S. Matteo, Clinica Oculistica dell'Università degli Studi di Pavia, Pavia, Italy. trimarch@unipv.it

Ophthalmologica. Journal International D'Ophtalmologie. International Journal of Ophthalmology. Zeitschrift Fur Augenheilkunde
|December 13, 2001
PubMed
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Deep lamellar keratoplasty (DLKP) shows superior outcomes compared to penetrating keratoplasty (PK). DLKP offers better endothelial cell density, reduced astigmatism, and improved vision with no rejection episodes.

Area of Science:

  • Ophthalmology
  • Corneal Surgery
  • Transplantation

Background:

  • Corneal stromal diseases often necessitate transplantation.
  • Penetrating keratoplasty (PK) is a common treatment but carries risks.
  • Preserving the endothelium is key for alternative surgical approaches.

Purpose of the Study:

  • To introduce a novel lamellar keratoplasty technique.
  • To compare deep lamellar keratoplasty (DLKP) with PK in matched patient cohorts.
  • To evaluate surgical outcomes based on specific clinical parameters.

Main Methods:

  • 150 DLKP procedures were performed on patients with stromal disease and healthy endothelium.
  • Each DLKP case was matched with a PK patient by age, gender, and pathology.

Related Experiment Videos

  • Outcomes assessed included rejection episodes, endothelial cell density, astigmatism, visual acuity, and ocular tension.

    • Main Results:

    • No rejection episodes occurred in the DLKP group, versus 4% in the PK group.
    • DLKP patients exhibited significantly higher endothelial cell density and lower astigmatism.
    • A statistically significant improvement in visual acuity was observed in DLKP patients.

    Conclusions:

    • DLKP is a preferred surgical option for corneal stromal diseases when the endothelium is intact.
    • The technique demonstrates improved safety and efficacy over PK in selected cases.
    • DLKP offers better visual outcomes and graft survival.