Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prediction of dissolution-absorption relationships from a continuous dissolution/Caco-2 system.

M J Ginski1, R Taneja, J E Polli

  • 1School of Pharmacy, University of Maryland, 20 North Pine Street, Baltimore, MD 21201, USA.

AAPS Pharmsci
|December 14, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Children's preferences among six novel moxifloxacin and linezolid-dispersible tablet formulations.

IJTLD open·2025
Same author

A novel home-based method for preparing suspensions of anti-TB drugs.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2023
Same author

Drug Permeability - Best Practices for Biopharmaceutics Classification System (BCS)-Based Biowaivers: A workshop Summary Report.

Journal of pharmaceutical sciences·2023
Same author

Stable, compounded bedaquiline suspensions to support practical implementation of pediatric dosing in the field.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2023
Same author

Extemporaneously compounded liquid formulations of clofazimine.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2023
Same author

Comparison of pharmacokinetics and bioavailability of bedaquiline fumarate, benzoate and maleate in dogs.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2023

A novel continuous dissolution/Caco-2 system accurately predicts drug absorption from oral formulations. This tool helps determine if drug release or cell permeability limits absorption, aiding in drug development.

Area of Science:

  • Pharmacokinetics
  • Drug Delivery
  • Biopharmaceutics

Background:

  • Predicting oral drug absorption is crucial for formulation development.
  • Dissolution and permeation are key factors influencing drug absorption kinetics.
  • Existing models may not fully capture the interplay between dissolution and absorption.

Purpose of the Study:

  • To design and validate a continuous dissolution/Caco-2 system for predicting drug dissolution-absorption relationships.
  • To compare in vitro predictions with in vivo clinical data for various drug formulations.
  • To assess the impact of excipients like croscarmellose sodium and solubilizing agents on drug absorption.

Main Methods:

  • A continuous system integrating a dissolution apparatus and a Caco-2 diffusion cell was developed.

Related Experiment Videos

  • Simultaneous dissolution and Caco-2 monolayer permeation studies were conducted.
  • Drug dissolution-absorption relationships were analyzed and compared with clinical study outcomes.

    • Main Results:

    • The continuous system successfully predicted dissolution-absorption relationships for piroxicam, metoprolol tartrate, and ranitidine HCl formulations.
    • The system accurately identified permeation-rate-limited and dissolution-rate-limited scenarios.
    • Croscarmellose sodium was shown to enhance ranitidine permeability, while solubilizing agents did not affect piroxicam permeability.

    Conclusions:

    • The continuous dissolution/Caco-2 system serves as a valuable experimental tool for predicting oral drug absorption.
    • This system can elucidate the rate-limiting steps (dissolution vs. permeation) in oral absorption.
    • The findings support the use of this integrated system in optimizing oral solid dosage form development.