Related Experiment Video
Updated: Aug 10, 2026

Assessing Murine Resistance Artery Function Using Pressure Myography
Published on: June 7, 2013
Blood pressure variability is increased in genetic hypertension and L-NAME -induced hypertension
1Department of Pharmacology, Basic Medical College, Second Military Medical University, Shanghai 200433, China.
Aim:
To examine whether the blood pressure variability (BPV) is increased in spontaneously hypertensive rats (SHR) and L-NAME-induced hypertensive rats (NHR).
Methods:
BPV was recorded with continuous hemodynamic monitoring in conscious un restrained rats. Time course of L-NAME-induced hypertension was measured by the tail-cuff method. Plasma NO concentration was determined by the method of nitric acid reductase.
Results:
In both SHR and NHR, systolic and diastolic BPV were significantly increased when compared with their respective controls. In S HR, in crease in diastolic BPV was predominant, whereas in NHR, increase in systolic BP V was predominant. Moreover, increase in systolic BPV in NHR (102 %) was obviously higher than that in SHR (28 %). Chronic administration of L-NAME 1 g/L in drink ing water caused a progressive increase in arterial blood pressure in rats. All rats were hypertensive at 4 weeks after treatment. Plasma NO level was decreased in NHR.
Conclusion:
Increased BPV is a general phenomenon in hypertension. NO is involved in the regulation of BPV.
Related Concept Videos
Factors affecting Blood pressure
Physiological Factors:
Alterations in Blood Pressure
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart beats)...
Hypertension and Regulation of Blood Pressure
Hypertension I: Introduction
Hypertension II: Pathophysiology
Hypertension III: Clinical Manifestations and Diagnostic Studies

