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DANCE in developing and injured lung.

Jyh-Chang Jean1, Ifeanyi Eruchalu, Yu Xia Cao

  • 1The Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA.

American Journal of Physiology. Lung Cellular and Molecular Physiology
|December 14, 2001
PubMed
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Multiple epidermal growth factor-like domains (DANCE) is a gene crucial for developing arteries and lung endothelial cell biology. Its expression is regulated during development and in response to lung injury, suggesting a role in repair.

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

Background:

  • Multiple epidermal growth factor-like domains (DANCE) is identified as a developmentally regulated gene.
  • DANCE mRNA shows significant changes in abundance during fetal and postnatal development.

Purpose of the Study:

  • To investigate the role of DANCE in developing arteries and lung endothelial cell biology.
  • To examine DANCE expression patterns in response to lung injury.

Main Methods:

  • Suppression-subtractive hybridization was used to identify DANCE.
  • Northern analysis and in situ hybridization were employed to study DANCE mRNA expression.
  • Hyperoxia-induced lung injury model in mice was used to assess DANCE induction.

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Main Results:

  • DANCE mRNA levels were highest in fetal and early postnatal stages, declining in adults but remaining high in lung, kidney, and spleen.
  • In adults, DANCE was abundant in pulmonary artery endothelium and lung epithelial type 2 cells.
  • DANCE mRNA was induced during the recovery phase after hyperoxia-induced lung injury in mice.

Conclusions:

  • DANCE plays a role in the biology of lung endothelial cells during development and repair after injury.
  • The regulated expression of DANCE suggests its involvement in vascular and lung tissue homeostasis.