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Covered retrievable tracheobronchial hinged stent: an experimental study in dogs
J C Hwang1, H Y Song, S G Kang
1Department of Diagnostic Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul. jchwang@uuh.ulsan.kr
Journal of Vascular and Interventional Radiology : JVIR
|December 14, 2001
Summary
This study shows that a novel covered retrievable tracheobronchial hinged stent is safe and feasible for airway support. Histopathologic airway changes resolved two weeks after stent removal in dogs.
Area of Science:
- Veterinary Medicine
- Pulmonology
- Biomaterials Science
Background:
- Tracheobronchial stents are used to manage airway obstructions.
- Covered, retrievable stents offer potential advantages in terms of safety and ease of removal.
- Investigating the histopathologic effects of these stents is crucial for understanding their impact on airway healing.
Purpose of the Study:
- To assess the safety and technical feasibility of a novel covered retrievable tracheobronchial hinged stent.
- To evaluate the histopathologic changes in the airway following stent placement and subsequent removal in a canine model.
Main Methods:
- A hinged tracheobronchial stent, constructed from nitinol wire and coated with polyurethane, was developed.
- Twenty stents were implanted in the lower trachea and main bronchi of 20 dogs under fluoroscopic guidance.
- Stents were removed after 4 or 8 weeks, with subsequent histopathologic examination of airway tissues.
Main Results:
- Successful stent placement was achieved in all subjects.
- Stent migration occurred in 35% of cases, and pneumonia was observed in three dogs.
- Significant granulation tissue and inflammation were noted immediately post-removal, which resolved to near-normal by two weeks.
Conclusions:
- The covered retrievable tracheobronchial hinged stent demonstrates feasibility for placement and removal.
- Airway histopathology associated with the stent returned to normal levels two weeks after removal.