Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Functional MRI changes during panic anticipation and imagery exposure.

A Bystritsky1, D Pontillo, M Powers

  • 1Department of Psychiatry, UCLA/NPI, 300 UCLA Medical Plaza, 2335 Los Angeles, CA 90095, USA.

Neuroreport
|December 14, 2001
PubMed
Summary

Brain imaging reveals distinct neural activity patterns in panic disorder patients during high anxiety. This suggests specific brain circuits may contribute to the psychopathology of panic disorder and emotional memory encoding.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stress resilience: a predictor of social independence.

Anxiety, stress, and coping·2026
Same author

Images of social support reminders, but not learned safety signals, reduce long-term fear.

Scientific reports·2025
Same author

Sensory over-responsivity and atypical neural responses to socially relevant stimuli in autism.

Autism research : official journal of the International Society for Autism Research·2024
Same author

Social support and fear-inhibition: an examination of underlying neural mechanisms.

Social cognitive and affective neuroscience·2024
Same author

Transcranial focused ultrasound for the treatment of tremor: A preliminary case series.

Brain stimulation·2023
Same author

Quantitative biodistribution of nanoparticles in plants with lanthanide complexes.

Scientific reports·2023

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Panic disorder is a debilitating psychiatric condition.
  • Understanding the neural underpinnings of panic disorder is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate brain activity differences between panic disorder patients and healthy controls during induced anxiety.
  • To identify neural circuits involved in the psychopathology of panic disorder.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was used to monitor brain activity.
  • Participants (panic disorder patients and controls) engaged in directed imagery of neutral and high anxiety situations.
  • Statistical Parametric Mapping (SPM99b) was employed for brain activity comparison.

Related Experiment Videos

Main Results:

  • Panic disorder patients exhibited increased activity in the inferior frontal cortex, hippocampus, and cingulate cortex (anterior and posterior) during high anxiety.
  • This heightened activity extended to the orbitofrontal cortex and involved both brain hemispheres.
  • Control subjects did not show similar patterns of activation.

Conclusions:

  • The identified brain regions may form a critical circuit in the psychopathology of panic disorder.
  • This neural pattern could facilitate the encoding and retrieval of emotional events, potentially contributing to panic disorder development in susceptible individuals.