Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Lower dopamine transporter binding potential in striatum during depression.

J H Meyer¹, S Krüger, A A Wilson

¹PET Imaging Centre, and Mood Division, Centre for Addiction and Mental Health, Department of Psychiatry and University of Toronto, 250 College St., Toronto, Ont. M5T1R8, Canada.

|December 14, 2001

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Consensus on Subdomains and Measures of Relevance to Affective and Social Cognition Research on Bipolar Disorder (CAS-BD); Outcomes and Recommendations From an International Society for Bipolar Disorders Targeting Cognition Taskforce Study.

Bipolar disorders·2026

Same author

Cold neutron radiation dose effects on a <sup>6</sup>LiF:ZnS(Ag) neutron detector with wavelength shifting fibers and SiPM photodetector.

Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment·2024

Same author

Heat Transport Capability and Fluid Flow Neutron Radiography of Three-Dimensional Oscillating Heat Pipes.

Journal of heat transfer·2021

Same author

Thermal and Visual Observation of Water and Acetone Oscillating Heat Pipes.

Journal of heat transfer·2021

Same author

Tools for optimising pharmacotherapy in psychiatry (therapeutic drug monitoring, molecular brain imaging and pharmacogenetic tests): focus on antidepressants.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry·2021

Same author

Willingness to pay for kidney transplantation among chronic kidney disease patients in Ghana.

PloS one·2020

Major depressive episodes (MDE) are linked to lower dopamine transporter (DAT) binding potential (BP) in the striatum. This suggests reduced dopamine transporter density, impacting dopamine clearance and cognitive function in depression.

Area of Science:

Neuroscience
Psychiatry
Molecular Imaging

Background:

Major depressive episodes (MDE) are hypothesized to involve a dopamine-lowering process.
The dopamine transporter (DAT) plays a crucial role in regulating extracellular dopamine levels.

Purpose of the Study:

To investigate the role of dopamine transporter binding potential (DAT BP) in the striatum during MDE.
To examine the relationship between DAT BP and dopamine-related neuropsychological symptoms in depressed individuals.

Main Methods:

Utilized positron emission tomography (PET) with the radiotracer [(11)C]RTI-32 to measure DAT BP in the striatum.
Compared DAT BP in subjects with MDE and healthy controls.
Correlated striatal DAT BP with performance on neuropsychological tests assessing dopamine-implicated symptoms.

Related Experiment Videos

Main Results:

Subjects with MDE exhibited significantly lower striatal DAT BP compared to healthy controls.
A significant inverse correlation was observed between striatal DAT BP and performance on dopamine-related neuropsychological tests.
Lower DAT BP was associated with better performance on these tests, suggesting a compensatory mechanism.

Conclusions:

Reduced striatal DAT BP in MDE is consistent with DAT downregulation in response to a dopamine-lowering process.
Lower DAT BP may represent a compensatory mechanism that influences dopamine clearance and affects cognitive function in depression.
These findings highlight the involvement of the dopamine system in the pathophysiology of MDE.