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Updated: Oct 3, 2026

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
Published on: April 22, 2022
Polyphenols newly extracted in red wine from southwestern France by centrifugal partition chromatography
X Vitrac1, C Castagnino, P Waffo-Téguo
1Groupe d'Etude des Substances Naturelles à Intérêt Thérapeutique EA491, Université de Bordeaux 2, Faculté des Sciences Pharmaceutiques, 3, Place de la Victoire, 33076 Bordeaux Cédex, France.
Abstract:
Polyphenols from the ethyl acetate extracts of red wine were successfully fractionated using a four-step process (solvent extraction, ion-exchange column chromatography, centrifugal partition chromatography, and semipreparative HPLC), which resulted in the isolation of 22 compounds belonging to different classes of polyphenols (stilbenes, cinnamic acids, flavonoids). Five of them are red wine constituents reported for the first time. The newly isolated compounds include resveratrol dimers, dihydroflavonols, and a cinnamic derivative.
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