Related Experiment Video

Updated: Oct 3, 2026

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
05:25

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft

Published on: September 15, 2023

The mid-term results of ventricular containment (ACORN WRAP) for end-stage ischemic cardiomyopathy

J S Raman1, M Hata, M Storer

  • 1Department of Cardiac Surgery, Austin & Repatriation Medical Centre, University of Melbourne, Australia.

Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
|December 18, 2001
PubMed

Insights

The Acorn Cardiac Support Device (ACSD) shows promise in treating heart failure by preventing cardiac dilation. This surgical intervention improved key heart function metrics in patients with ischemic cardiomyopathy over 12 months.

Area of Science:

  • Cardiology
  • Biomedical Engineering
  • Surgical Innovation

Background:

  • Heart failure, particularly due to ischemic cardiomyopathy, often leads to progressive cardiac dilation.
  • Existing treatments may not fully address the mechanical aspects of cardiac remodeling.
  • The Acorn Cardiac Support Device (ACSD) aims to provide external support to the failing heart.

Purpose of the Study:

  • To evaluate the mid-term efficacy of the Acorn Cardiac Support Device (ACSD) in patients with symptomatic heart failure.
  • To assess the impact of ACSD on cardiac dimensions, function, and clinical status in ischemic cardiomyopathy.
  • To determine the safety and feasibility of ACSD implantation alongside other cardiac procedures.

Main Methods:

  • Surgical implantation of the ACSD in six patients with symptomatic heart failure.
  • Concomitant procedures included coronary artery bypass grafting and ventricular reconstruction in most patients.
  • Postoperative monitoring for 12 months included echocardiographic measurements (LVEDD, LVESD, LVEF), mitral regurgitation assessment, and NYHA functional classification.

Main Results:

  • Significant reductions in left ventricular end-diastolic diameter (LVEDD) and left ventricular end-systolic diameter (LVESD) were observed one month post-surgery.
  • NYHA functional class improved significantly from a mean of 3 to 1.4 at 12 months.
  • While mitral regurgitation and LVEF showed improvement, these changes did not reach statistical significance. No late deaths or heart failure readmissions occurred.

Conclusions:

  • Ventricular containment using the ACSD appears beneficial in preventing cardiac dilation in patients with ischemic cardiomyopathy.
  • Mid-term results suggest ACSD is a feasible and potentially effective adjunctive therapy for heart failure.
  • Further randomized, long-term studies are warranted to establish the definitive role of ACSD in heart failure management.

More Related Videos

Operating Transverse Aortic Constriction with Absorbable Suture to Obtain Transient Myocardial Hypertrophy07:02

Operating Transverse Aortic Constriction with Absorbable Suture to Obtain Transient Myocardial Hypertrophy

Published on: September 9, 2020

Related Concept Videos

Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...