[Studies on the penetrability of skin (author's transl)]

Subcutaneous implantation of small pieces of plastic foam leads to an exudation, the amount of which can be influenced by experimental conditions. The reproducibility of the amount of the exudation is very satisfactory. For 3 examples the possibility could be demonstrated that after cutaneous application of specific substances these can be analysed in the exudate. This could be done in the case of escin and salicylic acid (which is formed from the applied ester by enzymatic break-down during penetration of the epidermis) using thin-layer chromatography while heparin could be demonstrated disc-electrophoretically. All these substances lead to a statistically significant effect on the exudation process. Combining the 3 substances the therapeutic effect is very long lasting.