Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

BMPs induce dermal markers and ectopic feather tracts.

Martin Scaal1, Felicitas Pröls, Ernst Martin Füchtbauer

  • 1Institute of Anatomy, University of Freiburg, Albertstrasse 17, D-79104 Freiburg, Germany.

Mechanisms of Development
|December 18, 2001
PubMed
Summary

Bone morphogenetic protein-2 (BMP-2) applied early to chick embryos creates dense dermis, promoting feather development. This study reveals BMPs

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A scoping review of the evidence supporting antiarrhythmic use after paediatric cardiac surgery.

Cardiology in the young·2026
Same author

Obesity Pharmacotherapy: An Urgent Need for Progressing Science, Access, and Equity-JACC: Advances Expert Panel.

JACC. Advances·2026
Same author

Comparison of laryngeal tube evo with tracheal intubation during intra-arrest-ventilation using biphasic positive pressure ventilation - a prospective randomized controlled body donor study.

Critical care (London, England)·2026
Same author

Development of the abdominal musculature in the chicken embryo.

Journal of anatomy·2026
Same author

Loss of Atoh8 Impairs Macroautophagy.

Cells·2025
Same author

Influence of different airway devices on intra-arrest ventilation during bag-valve-device ventilation - a prospective randomized controlled cadaver study.

Critical care (London, England)·2025

Area of Science:

  • Developmental biology
  • Molecular signaling in embryogenesis
  • Amniote skin and feather development

Background:

  • Bone morphogenetic proteins (BMPs) are crucial for embryonic development, including skin formation in amniotes.
  • The precise molecular mechanisms by which BMPs regulate dermal condensation and feather initiation remain incompletely understood.

Purpose of the Study:

  • To investigate the role of early BMP-2 application in inducing dermal development and feather formation in chick embryos.
  • To elucidate the downstream signaling pathway involving BMPs and cDermo-1 in dermal cell condensation and feather tract formation.

Main Methods:

  • Early application of BMP-2 to the lateral trunk of chick embryos.
  • Analysis of dermal marker gene expression (Msx-1, cDermo-1, beta-catenin).

Related Experiment Videos

  • Histological examination of dermal density and feather tract formation.
  • Detailed analysis of cDermo-1 expression patterns during early feather development.

    • Main Results:

    • BMP-2 application induced dense dermis formation, competent for feather development.
    • BMPs upregulated dermal markers Msx-1 and cDermo-1, promoting dermal proliferation and beta-catenin expression.
    • Ectopic feather tracts formed in previously featherless skin regions, indicating a role in feather patterning.

    Conclusions:

    • Early BMP-2 signaling is sufficient to induce a feather-forming dermis in chick embryos.
    • cDermo-1 acts downstream of BMP signaling, mediating dermal cell condensation.
    • BMP and cDermo-1 play critical roles in the development of dermis and feather primordia.