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Incidence of enteric adenovirus gastroenteritis in Iranian children
H Saderi1, M H Roustai, F Sabahi
1Department of Microbiology, Faculty of Medicine, Shahed University, Keshavarz Blvd. Dehkade Ave. No. 29, Tehran, Iran. saderih@yahoo.com
Insights
Enteric adenoviruses, including adenovirus 40 (Ad40) and adenovirus 41 (Ad41), were detected in Iranian children with gastroenteritis. This study marks the first demonstration of these viruses in Iran, highlighting their prevalence in pediatric cases.
Area of Science:
- Virology
- Pediatrics
- Infectious Diseases
Background:
- Enteric adenoviruses (adenovirus 40 and 41) are significant causes of pediatric gastroenteritis globally.
- Limited data existed on the prevalence of enteric adenoviruses in Iran prior to this study.
Purpose of the Study:
- To determine the incidence of enteric adenoviruses (Ad40 and Ad41) in children with gastroenteritis in Iran.
- To establish baseline data for adenovirus prevalence in pediatric gastroenteritis cases in the region.
Main Methods:
- A total of 872 stool specimens were collected from children under 7 years old presenting with gastroenteritis.
- Enzyme immunoassay using monoclonal antibodies was employed to detect adenovirus genus, Ad40, and Ad41.
Main Results:
- Enteric adenoviruses were identified in 6.7% of samples (3.3% Ad40, 3.4% Ad41).
- Nonenteric adenoviruses were found in 2.0% of samples.
- Watery diarrhea was a common symptom (86.4%) in adenovirus-infected children.
Conclusions:
- This study provides the first evidence of enteric and nonenteric adenoviruses in Iranian children with gastroenteritis.
- Adenoviruses are present in a considerable proportion of pediatric gastroenteritis cases in Iran.
- Findings underscore the importance of considering adenoviruses in the differential diagnosis of pediatric gastroenteritis in Iran.
Background:
Enteric adenoviruses, i.e. adenovirus 40 (Ad40) and adenovirus 41 (Ad41), have been shown to be a substantial cause of pediatric gastroenteritis in various parts of the world, but no data are available for Iran.
Objective:
The present study was performed to determine the incidence of enteric adenoviruses in children presenting to the Children's Medical Center with gastroenteritis in Iran.
Study Design:
Stool specimens from 872 children less than 7 years of age attending the Children's Medical Center in Tehran, Iran, with gastroenteritis were tested for the presence of Ad40, Ad41, and adenovirus-genus by a monoclonal antibody-based enzyme immunoassay.
Results And Conclusion:
6.7% of stool specimens contained enteric adenoviruses (3.3% Ad40 and 3.4% Ad41) and 2.0% nonenteric adenoviruses. Mean ages of Ad40, Ad41 and NEAd-positive children were 21, 19 and 29 months, respectively. Among the adenovirus-positive patients, 53.9% were male and 46.1% female. Watery diarrhea was present in 86.4% of children infected by adenoviruses. In conclusion, for the first time, we demonstrated the presence of enteric and nonenteric adenoviruses in a considerable proportion of stool samples from Iranian children with gastroenteritis.