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Published on: September 10, 2021

Incidence of enteric adenovirus gastroenteritis in Iranian children

H Saderi1, M H Roustai, F Sabahi

  • 1Department of Microbiology, Faculty of Medicine, Shahed University, Keshavarz Blvd. Dehkade Ave. No. 29, Tehran, Iran. saderih@yahoo.com

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
|December 18, 2001
PubMed

Insights

Enteric adenoviruses, including adenovirus 40 (Ad40) and adenovirus 41 (Ad41), were detected in Iranian children with gastroenteritis. This study marks the first demonstration of these viruses in Iran, highlighting their prevalence in pediatric cases.

Area of Science:

  • Virology
  • Pediatrics
  • Infectious Diseases

Background:

  • Enteric adenoviruses (adenovirus 40 and 41) are significant causes of pediatric gastroenteritis globally.
  • Limited data existed on the prevalence of enteric adenoviruses in Iran prior to this study.

Purpose of the Study:

  • To determine the incidence of enteric adenoviruses (Ad40 and Ad41) in children with gastroenteritis in Iran.
  • To establish baseline data for adenovirus prevalence in pediatric gastroenteritis cases in the region.

Main Methods:

  • A total of 872 stool specimens were collected from children under 7 years old presenting with gastroenteritis.
  • Enzyme immunoassay using monoclonal antibodies was employed to detect adenovirus genus, Ad40, and Ad41.

Main Results:

  • Enteric adenoviruses were identified in 6.7% of samples (3.3% Ad40, 3.4% Ad41).
  • Nonenteric adenoviruses were found in 2.0% of samples.
  • Watery diarrhea was a common symptom (86.4%) in adenovirus-infected children.

Conclusions:

  • This study provides the first evidence of enteric and nonenteric adenoviruses in Iranian children with gastroenteritis.
  • Adenoviruses are present in a considerable proportion of pediatric gastroenteritis cases in Iran.
  • Findings underscore the importance of considering adenoviruses in the differential diagnosis of pediatric gastroenteritis in Iran.
Abstract

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