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Interdependence of flow between lobes reduces maximal emptying postresection in dogs
David Ewing-Bui1, Steven N Mink
1Section of Thoracic Surgery, Department of Surgery, and Section of Respiratory Diseases, Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada R3E-0Z3.
Journal of Applied Physiology (Bethesda, Md. : 1985)
|December 18, 2001
Summary
Pulmonary resection may alter airway pressure dynamics, affecting maximal lung emptying. Lower lobe emptying decreased when deflating alone compared to both lungs deflated or after pneumonectomy.
Area of Science:
- Pulmonary physiology
- Respiratory mechanics
- Surgical outcomes
Background:
- Pulmonary resection is a common surgical procedure.
- Understanding its impact on remaining lung function is crucial.
- Maximal lung emptying dynamics after resection are not fully understood.
Purpose of the Study:
- To investigate the effect of pulmonary resection on maximal emptying of remaining lung lobes.
- To compare lobe emptying under three conditions: both lungs deflated (BL), one lung removed (OL), and lower lobe deflating alone (LA).
Main Methods:
- Open-chest canine preparation with normal and emphysematous lungs.
- Alveolar capsule technique to measure alveolar pressure (Palv) at varying vital capacities (VC).
- Pitot-static tube technique to measure intrabronchial pressures and estimate bronchial properties.
Main Results:
- Maximal deflation rates (dPalv/dt) and maximal lobar flows (lobarV(max)) decreased significantly during lower lobe alone (LA) deflation compared to BL and OL (P < 0.05).
- This reduction was attributed to decreased bronchial area during LA, limiting flow.
- No significant differences were observed between normal and emphysematous lung lobes.
Conclusions:
- Lower lobe emptying is reduced when deflating alone, likely due to altered bronchial pressure-area behavior.
- Pulmonary resection may impact central airway pressure dynamics.
- Mechanisms like altered axial tension or interdependence may explain observed changes in airway collapsibility.