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Rapidly progressive glomerulonephritis due to rifampicin therapy
Keiji Yoshioka1, Norio Satake, Yoshihiro Kasamatsu
1First Department of Internal Medicine, Matsushita Memorial Hospital, Moriguchi, Osaka, Japan.
Nephron
|December 18, 2001
Abstract:
A 60-year-old man was treated with rifampicin, isoniazid, ethambutol and pyrazinamide for pulmonary tuberculosis. Acute renal failure developed 1 month after re-administration of rifampicin following 1 month's interruption of treatment. A renal biopsy showed crescentic lesions characteristic of rapidly progressive glomerulonephritis. This is, to our knowledge, the fourth case of rapidly progressive crescentic glomerulonephritis associated with rifampicin treatment, which responded to methylprednisolone pulse therapy followed by oral steroid therapy.