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Related Experiment Videos

Does serum calcium in pre-eclampsia and normal pregnancy differ?

N O Malas1, Z M Shurideh

  • 1Department of Obstetrics & Gynecology, King Hussein Medical Centre, Fetal Medicine Sub-speciality at Queen Charlotte's Hospital, PO Box 352-11621, Amman, Jordan.

Saudi Medical Journal
|December 18, 2001
PubMed
Summary

Pregnancy-induced hypertension is linked to lower maternal serum calcium and higher parathyroid hormone levels. This suggests calcium may play a role in developing this condition during pregnancy.

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Area of Science:

  • Obstetrics and Gynecology
  • Endocrinology
  • Maternal-Fetal Medicine

Background:

  • Pregnancy-induced hypertension (PIH) is a significant complication of pregnancy.
  • Calcium and parathyroid hormone (PTH) play crucial roles in physiological regulation.
  • Altered calcium metabolism has been implicated in various hypertensive disorders.

Purpose of the Study:

  • To investigate serum calcium and parathyroid hormone levels in pregnant women with PIH compared to those with normal pregnancies.
  • To explore the potential relationship between calcium, PTH, and the development of PIH.

Main Methods:

  • A comparative study involving 80 pregnant women.
  • Study group: 50 women with PIH.
  • Control group: 30 women with normal pregnancies, enrolled from the first or second trimester.

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Main Results:

  • Mean serum total calcium was significantly lower in the PIH group (8.22 mg%) compared to the normal pregnancy group (9.50 mg%) (P<0.005).
  • Serum parathyroid hormone concentration was significantly higher in the PIH group (P<0.005).

Conclusions:

  • Maternal serum total calcium and parathyroid hormone levels are associated with pregnancy-induced hypertension.
  • Low maternal serum calcium may contribute to the pathogenesis of PIH.
  • Calcium supplementation in late pregnancy warrants further investigation for PIH prevention, though evidence is currently limited.