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Gallbladder pathologies and cholelithiasis
1Department of Histopathology, King Abdulaziz University Hospital, PO Box 6615, Jeddah 21452, Kingdom of Saudi Arabia. ibm979@hotmail.com
Insights
Gallbladder diseases, primarily gallstones, are common, with women disproportionately affected. This study analyzed 740 cholecystectomies, finding benign lesions like chronic cholecystitis are most prevalent.
Area of Science:
- Medical Science
- Surgical Pathology
- Epidemiology
Background:
- Cholecystectomy is a frequent surgical procedure, often indicated for cholelithiasis (gallstones).
- Understanding the demographics and pathology of gallbladder disease is crucial due to its high incidence and healthcare resource utilization.
- This study aims to detail gallbladder disease patterns in the Kingdom and compare them with existing literature.
Purpose of the Study:
- To analyze the age and sex distribution of gallbladder diseases.
- To identify the prevalence of various gallbladder pathologies, including cholelithiasis.
- To conduct a comparative analysis with other studies within the Kingdom.
Main Methods:
- Retrospective analysis of 740 consecutive gallbladder cholecystectomies over 3.5 years.
- Tabulation of main gallbladder pathologies and the number of gallbladders with stones.
- Analysis of age and sex distribution for gallbladder pathology and gallstones.
Main Results:
- A total of 740 cases were reviewed, with females comprising 82% (female to male ratio 4.6:1).
- Benign lesions accounted for 99% of cases (mean age 36), predominantly chronic cholecystitis (97%).
- Malignant lesions were rare, constituting 1% (7 cases) with a mean age of 65.
Conclusions:
- Gallbladder pathologies are highly prevalent, consistent with findings from comparative analyses of 7 other studies.
- The mean cholecystectomy rate in the Kingdom is approximately 10%.
- The overall mean age for cholecystectomy patients was 37.05 years, with males averaging 42.26 and females 37.25.
Objective:
Cholecystectomy, mostly due to cholelithiasis is one of the most common surgical procedures utilizing a significant amount of healthcare resources. As there are a huge number of cases, for example approximately 300 cases per year in our region, outlines this commonly encountered lesion should be recorded. Also, in an attempt to delineate the outline of the pattern, age and sex distribution of gallbladder diseases in the whole Kingdom, a comparative analysis is also included in this study with 7 other studies published from different parts of the Kingdom.
Methods:
Our study consisted of 740 consecutive gallbladder cholecyctectomies mostly for cholelithiasis received in a time frame of 3.5 years (for example between January 1997 through to May 2000) by the Department of Histopathology retrieved from the records of the laboratory. The outline of main gallbladder pathologies was tabulated. The number of gallbladders received with stones was also calculated. Age and sex distribution for gallbladder pathology and gallstones was also tabulated.
Results:
There were 131 males (18%) and 609 (82%) females, with a female ratio male 4.6:1. Benign lesions comprised 99% (mean age 36), mostly chronic cholecyctitis (97%) and acute cholecystitis which constituted 15 cases only (2%), malignant lesions comprised only 7 cases for example 1% of all lesions (mean age 65).
Conclusion:
Gallbladder pathologies are very common and similar results have been obtained from other studies by comparative analysis. The mean cholecystectomy rates in the Kingdom totalled approximately 10%, mean age for all cholecystectomy diseases in both sexes equalled 37.05. The mean age for males was 42.26, females 37.25 and their ratio was 44.5:1.