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Related Experiment Videos

Resorbable polymer fibers for ligament augmentation.

L Dürselen1, M Dauner, H Hierlemann

  • 1Institute of Orthopaedic Research and Biomechanics, University of Ulm, Germany. lutz.duerselen@medizin.uni-ulm.de

Journal of Biomedical Materials Research
|December 18, 2001
PubMed
Summary

New resorbable augmentation devices are needed for ligament surgery as current materials degrade too quickly. Researchers explored poly(L-lactide) and poly(L-lactide-co-glycolide) fibers to find a material with suitable mechanical properties for graft healing.

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Area of Science:

  • Biomaterials Science
  • Orthopedic Surgery
  • Polymer Chemistry

Background:

  • Current resorbable augmentation devices for ligament surgery offer limited protection due to rapid degradation (4-6 weeks half-life tensile strength).
  • Ligament graft healing and revitalization can take up to 12 months, necessitating longer-lasting support.
  • A desirable device should exhibit gradually decreasing mechanical properties with a half-time strength of at least 6 months.

Purpose of the Study:

  • To investigate the degradation kinetics of resorbable fibers made from poly(L-lactide) and poly(L-lactide-co-glycolide).
  • To evaluate the influence of processing and treatment parameters on the mechanical properties and degradation rates of these fibers.
  • To identify suitable materials for developing improved resorbable augmentation devices for cruciate ligament surgery.

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Main Methods:

  • Fibers made of poly(L-lactide) and poly(L-lactide-co-glycolide) were subjected to various treatments (thermal posttreatment, irradiation, diameter modification).
  • In vitro degradation studies were conducted over 72 weeks.
  • Mechanical properties (tensile strength, stiffness) and molecular weight were measured at various time points.

Main Results:

  • The half-time strength of the tested materials varied significantly, ranging from 5 to 64 weeks, depending on treatment parameters.
  • While tensile strength degradation was observed, the stiffness of the materials did not decrease adequately.
  • Inadequate stiffness reduction may hinder the gradual increase in graft load necessary for collagenous tissue stimulation.

Conclusions:

  • Poly(L-lactide) and poly(L-lactide-co-glycolide) fibers offer a range of degradation profiles, with some achieving the desired long-term mechanical support.
  • A novel augmentation construct design is proposed, utilizing a braid of multiple, differentially degrading fiber types.
  • This braided design would allow for a gradual decrease in construct stiffness as faster-degrading components break down, promoting optimal graft healing.