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Single Cell Measurement of Dopamine Release with Simultaneous Voltage-clamp and Amperometry
Published on: November 21, 2012
Amperometric determination of dipyrone in pharmaceutical formulations with a flow cell containing gold electrodes
R A Muñoz1, R C Matos, L Angnes
1Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes, 748, 05508-900-São Paulo, SP, Brasil.
Abstract:
A simple, rapid, and precise amperometric method for quantification of dipyrone in pharmaceutical formulations is presented. The proposed method permits determinations in the 10(-7) mol L(-1) of the analyte and enables 90 determinations h(-1), employing only 100 microL of sample per determination. This method is based on the direct quantification of dipyrone in many pharmaceutical products, avoiding cumbersome processes such as previous separations, solvent extraction, or sample filtration. This new procedure was applied to commercial pharmaceutical tablets, and the results obtained were in excellent agreement with the ones obtained by the classical iodometric method.
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