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Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic Poly(I:C)
07:13

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Published on: March 25, 2016

Maternal UPD 20 in an infant from a pregnancy with mosaic trisomy 20

I S Salafsky1, S N MacGregor, U Claussen

  • 1Division of Genetics, Evanston Hospital, Northwestern University Medical School, Evanston, IL 60201, USA.

Prenatal Diagnosis
|December 18, 2001
PubMed

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During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.
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