Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gm and Inv allotypes in premature infants.

M Daveau, L Rivat, C Ropartz

    Biomedicine / [Publiee Pour L'A.A.I.C.I.G.]
    |February 10, 1975
    PubMed
    Summary

    Maternal and fetal immunoglobulin G (IgG) subclasses cross the placenta. Fetal production of certain IgG allotypes in utero, influenced by paternal genes, was confirmed in newborns.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Chromosomal assignments of mammalian genes with an acute inflammation-regulated expression in liver.

    Immunogenetics·2002
    Same author

    Gene transcription in hepatocytes during the acute phase of a systemic inflammation: from transcription factors to target genes.

    Inflammation research : official journal of the European Histamine Research Society ... [et al.]·2001
    Same author

    Up-regulated expression of HGF in rat liver cells after experimental endotoxemia: a potential pathway for enhancement of liver regeneration.

    Growth factors (Chur, Switzerland)·2001
    Same author

    Differential expression of apoptosis-associated genes post-hepatectomy in cirrhotic vs. normal rats.

    Apoptosis : an international journal on programmed cell death·2001
    Same author

    Influence of glutamine on cytokine production by human gut in vitro.

    Cytokine·2001
    Same author

    Fetuin-B, a second member of the fetuin family in mammals.

    The Biochemical journal·2000

    Area of Science:

    • Immunology
    • Maternal-Fetal Medicine
    • Genetics

    Background:

    • Immunoglobulin G (IgG) subclasses are crucial for immune defense.
    • Placental transfer of maternal IgG to the fetus is a known physiological process.
    • Understanding fetal IgG production and transfer is vital for neonatal immunity.

    Purpose of the Study:

    • To confirm the placental transfer of all four IgG subclasses from mother to fetus.
    • To investigate the presence of fetal-derived IgG allotypes in cord serum.
    • To explore the relationship between IgG levels and gestational age.

    Main Methods:

    • Haemagglutination inhibition tests specific for Gm allotypes.
    • Tests for IgG4 subclass.
    • Analysis of maternal and cord serum samples from 90 cases.

    Main Results:

    • Placental transfer of all four IgG subclasses was confirmed.
    • In 31 out of 90 cases, cord serum contained Gm allotypes absent in maternal serum, indicating fetal production.
    • Fetal-derived Gm allotypes are dependent on paternal genes.
    • A positive correlation was observed between the logarithm of IgG level and gestational age (r = 0.59, p < 0.001).

    Conclusions:

    • The study confirms placental transfer of all IgG subclasses.
    • Evidence suggests active fetal IgG production in utero, influenced by paternal genetics.
    • IgG levels increase with advancing gestational age, highlighting developmental changes in fetal immunity.

    Related Experiment Videos