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Rapid quantitative lung (1)H T(1) mapping.

P M Jakob1, C M Hillenbrand, T Wang

  • 1Department of Physics, University of Würzburg, Würzburg, Germany. peja@physik.uni-wuerzburg.de

Journal of Magnetic Resonance Imaging : JMRI
|December 18, 2001
PubMed
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This study introduces a fast T(1) mapping technique for the human lung, providing accurate quantitative T(1) values in under five seconds. The method demonstrated a significant difference in T(1) values when volunteers breathed room air versus 100% oxygen.

Area of Science:

  • Medical Imaging
  • Radiology
  • Physiology

Background:

  • Quantitative T(1) mapping is crucial for assessing lung tissue properties.
  • Existing methods for T(1) mapping can be time-consuming, limiting clinical applicability.
  • Rapid and robust techniques are needed for dynamic physiological studies of the lung.

Purpose of the Study:

  • To develop and validate a rapid, quantitative T(1) mapping technique for the human lung.
  • To assess the feasibility of T(1) mapping in under five seconds.
  • To investigate the effect of breathing different oxygen concentrations on lung T(1) values.

Main Methods:

  • Utilized a series of Snapshot FLASH tomograms acquired after a single inversion pulse.
  • Acquired quantitative T(1) parameter maps from six healthy volunteers.

Related Experiment Videos

  • Performed T(1) mapping while volunteers breathed room air and 100% oxygen.

    • Main Results:

    • High-quality, quantitative T(1) maps were obtained in less than five seconds.
    • Measured T(1) values were in good agreement with previously reported literature values.
    • A statistically significant difference (P < 0.0001) in T(1) values was observed between breathing room air and 100% oxygen.

    Conclusions:

    • The presented technique offers a rapid and robust method for quantitative lung T(1) mapping.
    • This technique has potential for dynamic physiological studies and clinical applications.
    • Changes in oxygenation significantly impact lung T(1) values, highlighting the technique's sensitivity.