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Related Experiment Videos

Dyslipidemia and a reversible decrease in insulin sensitivity induced by therapy with 13-cis-retinoic acid.

H A Koistinen1, A Remitz, H Gylling

  • 1Department of Medicine, Division of Geriatrics, Helsinki University Central Hospital, Helsinki, Finland. heikki_koistinen.yahoo.com

Diabetes/Metabolism Research and Reviews
|December 18, 2001
PubMed
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Isotretinoin (13-cis-retinoic acid) treatment for acne reduces insulin sensitivity and impairs glucose metabolism. These metabolic changes, including altered lipid profiles, resolve after treatment cessation.

Area of Science:

  • Endocrinology
  • Metabolic Medicine
  • Dermatology

Background:

  • 13-cis-retinoic acid (Roaccutan) is a common acne treatment.
  • Known to affect lipid and glucose metabolism.
  • Potential impact on insulin sensitivity requires investigation.

Purpose of the Study:

  • To determine if 13-cis-retinoic acid treatment decreases insulin sensitivity.
  • To assess changes in glucose and lipid metabolism during and after treatment.

Main Methods:

  • Studied 11 healthy men treated with Roaccutan for acne.
  • Measured insulin sensitivity using the euglycaemic hyperinsulinaemic clamp technique.
  • Assessed metabolic parameters before, during, and after treatment.

Main Results:

Related Experiment Videos

  • Reduced total, oxidative, and non-oxidative glucose disposal rates.
  • Observed a 4% increase in HbA1c.
  • Increased VLDL and LDL cholesterol, triglycerides, and phospholipids.

Conclusions:

  • Acne treatment with 13-cis-retinoic acid reduces insulin sensitivity.
  • Induces lipid metabolism alterations similar to insulin resistance syndrome.
  • Metabolic disturbances are reversible upon treatment cessation.