Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dyslipidemia and a reversible decrease in insulin sensitivity induced by therapy with 13-cis-retinoic acid.

H A Koistinen1, A Remitz, H Gylling

  • 1Department of Medicine, Division of Geriatrics, Helsinki University Central Hospital, Helsinki, Finland. heikki_koistinen.yahoo.com

Diabetes/Metabolism Research and Reviews
|December 18, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Factors associated with severity of atopic dermatitis - a Finnish cross-sectional study.

Journal of the European Academy of Dermatology and Venereology : JEADV·2022
Same author

The spectrum of skin-related conditions in primary care during 2015-2019-A Finnish nationwide database study.

Skin health and disease·2022
Same author

Safety of tacrolimus 0.03% and 0.1% ointments in young children with atopic dermatitis: a 36-month follow-up study.

Clinical and experimental dermatology·2021
Same author

Publisher Correction to: Development of the Asia Pacific Consortium on Osteoporosis (APCO) framework: clinical standards of care for the screening, diagnosis, and management of osteoporosis in the Asia-Pacific region.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2021
Same author

Development of the Asia Pacific Consortium on Osteoporosis (APCO) Framework: clinical standards of care for the screening, diagnosis, and management of osteoporosis in the Asia-Pacific region.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2021
Same author

Amiodarone disrupts cholesterol biosynthesis pathway and causes accumulation of circulating desmosterol by inhibiting 24-dehydrocholesterol reductase.

Journal of internal medicine·2020
Same journal

Analysis of Circulating Long Non-Coding RNA in Prediabetes or Newly Diagnosed Type 2 Diabetes Subjects With or Without Heart Stress.

Diabetes/metabolism research and reviews·2026
Same journal

Biomarkers for Diabetic Peripheral Artery Disease: An Integrated Review and Clinical Perspective.

Diabetes/metabolism research and reviews·2026
Same journal

Retinol, Carotenoid, and Tocopherol Intake and Status, and the Risk of Islet Autoimmunity and Type 1 Diabetes: The Environmental Determinants of Diabetes in the Young Study.

Diabetes/metabolism research and reviews·2026
Same journal

Glucokinase Regulatory Protein Gene Polymorphism as a Predictive Biomarker for Early Renal Injury in Newly Diagnosed Early-Onset Type 2 Diabetes Mellitus.

Diabetes/metabolism research and reviews·2026
Same journal

Hearing Loss in Adults With Diabetes and Prediabetes: A Systematic Review and Meta-Analysis.

Diabetes/metabolism research and reviews·2026
Same journal

The Effects of Glucagon-Like Peptide-1 Receptor Agonists and Sodium-Glucose Co-Transporter-2 Inhibitors on Lean Body Mass in Humans: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.

Diabetes/metabolism research and reviews·2026
See all related articles

Isotretinoin (13-cis-retinoic acid) treatment for acne reduces insulin sensitivity and impairs glucose metabolism. These metabolic changes, including altered lipid profiles, resolve after treatment cessation.

Area of Science:

  • Endocrinology
  • Metabolic Medicine
  • Dermatology

Background:

  • 13-cis-retinoic acid (Roaccutan) is a common acne treatment.
  • Known to affect lipid and glucose metabolism.
  • Potential impact on insulin sensitivity requires investigation.

Purpose of the Study:

  • To determine if 13-cis-retinoic acid treatment decreases insulin sensitivity.
  • To assess changes in glucose and lipid metabolism during and after treatment.

Main Methods:

  • Studied 11 healthy men treated with Roaccutan for acne.
  • Measured insulin sensitivity using the euglycaemic hyperinsulinaemic clamp technique.
  • Assessed metabolic parameters before, during, and after treatment.

Main Results:

Related Experiment Videos

  • Reduced total, oxidative, and non-oxidative glucose disposal rates.
  • Observed a 4% increase in HbA1c.
  • Increased VLDL and LDL cholesterol, triglycerides, and phospholipids.

Conclusions:

  • Acne treatment with 13-cis-retinoic acid reduces insulin sensitivity.
  • Induces lipid metabolism alterations similar to insulin resistance syndrome.
  • Metabolic disturbances are reversible upon treatment cessation.