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Arp2/3 complex: advances on the inner workings of a molecular machine
J A Cooper1, M A Wear, A M Weaver
1Department of Cell Biology, Washington University School of Medicine, Saint Louis, MO 63130, USA. jcooper@cellbio.wustl.edu
Cell
|December 19, 2001
Abstract:
Several new papers report progress on the structure and function of Arp2/3 complex. A crystal structure, a cryo-EM structure, and a reconstitution of the complex from subunits have been reported. New results also address the nucleation mechanism and the role of bound nucleotide.
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The nucleation phase involves forming a stable nucleus consisting of three actin monomers to form a new actin filament. Actin-binding proteins such as formins and Arp2/3 complex help filament growth post-nucleation. The Formins form straight actin...
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Arp2/3 Complex
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