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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Low hepatic lipase activity is a novel risk factor for coronary artery disease
K A Dugi1, K Brandauer, N Schmidt
1Department of Internal Medicine I, Internal Medicine III, University of Heidelberg, Heidelberg, Germany. klaus_dugi@med.uni-heidelberg.de
Circulation
|December 19, 2001
Summary
Low hepatic lipase (HL) activity is linked to coronary artery disease (CAD). This finding suggests HL may aid in CAD risk assessment and could be a target for new treatments.
Area of Science:
- Lipid Metabolism
- Cardiovascular Disease Research
- Biochemistry
Background:
- Hepatic lipase (HL) plays a key role in lipid metabolism.
- The association between HL activity and coronary artery disease (CAD) remains debated.
Purpose of the Study:
- To investigate the relationship between hepatic lipase activity and the extent of coronary artery disease.
- To explore the potential of HL activity as a biomarker for CAD risk.
Main Methods:
- Measured postheparin plasma HL activity in 200 men undergoing coronary angiography.
- Assessed CAD extent using a validated extent score.
- Performed multivariate analyses and examined genetic variations in the HL promoter (-514 T allele).
Main Results:
- A significant inverse correlation was found between HL activity and CAD extent (r=-0.19, P<0.01).
- Patients with CAD had lower HL activity compared to controls (286+/-106 vs. 338+/-108 nmol.mL(-1).min(-1), P<0.01).
- The HL promoter -514 T allele was associated with reduced HL activity and increased CAD extent.
Conclusions:
- Low hepatic lipase activity is independently associated with coronary artery disease.
- HL activity may serve as a valuable tool for estimating CAD risk.
- HL could be a potential target for future pharmacological interventions in CAD management.
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