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Related Experiment Videos

Apolipoprotein E genotype in Korean schizophrenic patients.

M K Lee1, A J Park, B Y Nam

  • 1Department of Clinical Pathology, Chung-Ang University College of Medicine, Seoul, Korea. cpworld@hananet.net

Journal of Korean Medical Science
|December 19, 2001
PubMed
Summary

The apolipoprotein E (APOE) genotype was investigated in Korean schizophrenia patients. APOE epsilon2 and epsilon3 allele frequencies differed significantly, suggesting APOE

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Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • The apolipoprotein E (APOE) epsilon4 allele is established as a risk factor for Alzheimer's disease.
  • The association between APOE genotype and schizophrenia risk remains controversial and requires further investigation.

Purpose of the Study:

  • To investigate the association between apolipoprotein E (APOE) genotypes and schizophrenia in a Korean population.
  • To compare APOE allele frequencies between schizophrenic patients and healthy controls.

Main Methods:

  • Study included 60 Korean patients diagnosed with schizophrenia and 60 healthy controls.
  • APOE genotyping was performed using a reverse hybridization-based line probe assay.

Main Results:

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  • Significant differences were observed in the distribution of APOE genotypes between the patient and control groups.
  • APOE epsilon2 and epsilon3 allele frequencies were significantly different in schizophrenic patients compared to controls.

    • Conclusions:

    • The findings suggest a potential role for APOE alleles in the pathogenesis of schizophrenic disorders.
    • APOE genotyping may offer insights into the genetic underpinnings of schizophrenia.