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Updated: Oct 3, 2026
Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence
Published on: October 25, 2011
Heterogeneity of apoptosis and proliferative activity within superficial spreading type early gastric cancer
Hirofumi Awata1, Kazuo Hirose, Akio Yamaguchi
1First Department of Surgery, School of Medicine, Fukui Medical University, Matsuoka-cho, Yoshida-gun, Fukui, Japan.
Abstract:
Using the in situ DNA nick end-labeling method and immunohistochemistry, the indices of apoptosis (AI) and Ki-67 labeling index (LI) among 3 different portions within the tumor (the central surface vs. the lateral margin or deepest portion) were determined and compared in 14 superficial spreading type early gastric cancers. The AI was the lowest and the LI remained high in the lateral margin compared with the central surface, whereas the AI remained high and the LI was the lowest in the deepest portion. This heterogeneity of apoptosis and proliferation within the tumor might be related to the predominantly horizontal growth of superficial spreading type early gastric cancer.
