Related Experiment Video

Updated: Aug 14, 2026

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine
10:05

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine

Published on: July 7, 2016

Effects of preoperative treatment with diltiazem on diastolic ventricular function after coronary artery bypass graft

J M van der Maaten1, A J de Vries, R H Henning

  • 1Department of Anesthesiology, University Hospital Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands. J.M.A.A.van.der.Maaten@anest.azg.nl

Journal of Cardiothoracic and Vascular Anesthesia
|December 19, 2001
PubMed

Insights

Preoperative diltiazem did not alter left ventricular diastolic function after coronary artery bypass graft (CABG) surgery. However, diltiazem may improve atrial systolic function post-CABG.

Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Pharmacology

Background:

  • Coronary artery bypass graft (CABG) surgery can impact left ventricular (LV) diastolic function.
  • Preoperative interventions are explored to mitigate postoperative cardiac dysfunction.

Purpose of the Study:

  • To investigate the effect of preoperative diltiazem on LV diastolic dysfunction following CABG surgery.
  • To assess if diltiazem preserves or improves diastolic function in patients undergoing CABG.

Main Methods:

  • Prospective, nonrandomized clinical study involving 34 patients undergoing elective CABG.
  • Patients were divided into diltiazem (n=17) and control (n=17) groups, both receiving beta-blockers.
  • Echocardiography (transesophageal echocardiography) and hemodynamic variables were measured at multiple time points, including post-cardiopulmonary bypass (CPB).

Main Results:

  • LV diastolic function was preserved post-CABG in both diltiazem and control groups.
  • Peak E and A velocities increased postoperatively but returned to baseline in controls.
  • Diltiazem showed a difference only in peak A velocity and time velocity integral of the A wave (TVI-A) at 4 hours post-CPB compared to controls.

Conclusions:

  • Preoperative diltiazem does not alter preserved LV diastolic function after CABG surgery.
  • The study suggests diltiazem may improve atrial systolic function in the postoperative period.
  • LV diastolic function remains preserved post-CABG in patients with preserved systolic function.
Abstract

More Related Videos

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery09:12

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery

Published on: March 27, 2018

Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery04:48

Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery

Published on: November 28, 2018

Related Concept Videos

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
Cardiac Catheterization I: Pre-Procedure Overview01:28

Cardiac Catheterization I: Pre-Procedure Overview

Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Cardiomyopathy VII: Pre and Post Operative Nursing Management01:28

Cardiomyopathy VII: Pre and Post Operative Nursing Management

Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...