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Related Experiment Videos

Thalamic deep brain stimulation: effects on the nontarget limbs.

W Ondo1, K Dat Vuong, M Almaguer

  • 1Department of Neurology, Baylor College of Medicine, Houston, Texas, USA. wondo@bcm.tmc.edu

Movement Disorders : Official Journal of the Movement Disorder Society
|December 19, 2001
PubMed
Summary

Unilateral VIM DBS effectively treats essential tremor (ET) and Parkinson's disease (PD) tremor. Ipsilateral tremor may mildly improve in ET patients, with no worsening or rebound augmentation observed after device deactivation.

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Area of Science:

  • Neurology
  • Neurosurgery
  • Biomedical Engineering

Background:

  • Unilateral VIM DBS is a standard treatment for ET and PD tremor.
  • The impact of unilateral VIM DBS on ipsilateral tremor has not been thoroughly investigated.
  • Understanding ipsilateral effects and deactivation responses is crucial for optimizing DBS therapy.

Purpose of the Study:

  • To systematically evaluate the effects of unilateral VIM DBS on ipsilateral tremor.
  • To assess tremor changes on the side contralateral to VIM DBS implantation.
  • To determine if deactivating the device causes tremor rebound augmentation.

Main Methods:

  • Seventy-three patients with ET or PD underwent unilateral VIM DBS.
  • Tremor was assessed approximately 3 months post-implantation using standardized rating scales.

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  • Evaluations included blinded and unblinded assessments, with and without device stimulation.

    • Main Results:

    • Contralateral tremor significantly improved in both ET and PD patients.
    • No worsening of ipsilateral tremor was observed.
    • Mild ipsilateral tremor improvement occurred in ET patients, but not PD patients.
    • No rebound tremor augmentation was noted upon device deactivation in either group.

    Conclusions:

    • Unilateral VIM DBS provides robust contralateral tremor control for ET and PD.
    • VIM DBS may offer mild ipsilateral tremor benefits in ET patients.
    • Concerns regarding significant ipsilateral tremor worsening or rebound augmentation post-deactivation are unfounded.