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Related Experiment Videos

Tardive dyskinesias in the elderly.

G Fabbrini1, P Barbanti, C Aurilia

  • 1Department of Neurological Sciences, University La Sapienza, Rome, Italy. Giovanni.Fabbrini@Uniroma1.it

International Journal of Geriatric Psychiatry
|December 19, 2001
PubMed
Summary

As the population ages, neuropsychiatric conditions requiring antipsychotics will rise. Atypical antipsychotics show promise in reducing tardive dyskinesias (TD) in older adults, similar to their effect in younger patients.

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Area of Science:

  • Geriatric Psychiatry
  • Neuropharmacology
  • Clinical Neurology

Background:

  • Aging populations are experiencing increased neuropsychiatric disorders like late-onset psychosis and dementia-related behavioral disturbances.
  • Antipsychotic medications are often necessary for these conditions but carry risks, particularly extrapyramidal symptoms and tardive dyskinesias (TD) in the elderly.
  • Tardive dyskinesias (TD) present complex challenges regarding risk factors, disease progression, and treatment efficacy, with potential for patient debilitation.

Purpose of the Study:

  • To evaluate the risk-benefit profile of antipsychotics in an aging population.
  • To explore the potential of atypical antipsychotics in preventing or reducing TD incidence in older individuals.
  • To compare the efficacy of atypical versus classic antipsychotics concerning TD development in elderly patients.

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Main Methods:

  • Review of existing clinical studies and basic science research on antipsychotic use in aged populations.
  • Analysis of data on the incidence of extrapyramidal disturbances and TD associated with different antipsychotic classes.
  • Examination of the pharmacological mechanisms of atypical antipsychotics (dopamine-serotonin antagonism) in relation to TD prevention.

Main Results:

  • Atypical antipsychotics demonstrate a lower incidence of TD in young schizophrenic patients compared to classic neuroleptics.
  • Emerging data suggests this protective effect of atypical antipsychotics against TD may extend to older patient populations.
  • Prevention of TD is a critical goal due to often disappointing treatment outcomes.

Conclusions:

  • Atypical antipsychotics appear to offer an advantage in managing neuropsychiatric disorders in the elderly by potentially lowering the risk of tardive dyskinesias.
  • Further research and clinical data are needed to solidify the role of atypical antipsychotics in preventing TD in aging individuals.
  • The findings support a shift towards considering atypical antipsychotics for older patients requiring long-term antipsychotic treatment.