Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polymer-supported lipid bilayers on benzophenone-modified substrates.

W W Shen1, S G Boxer, W Knoll

  • 1Department of Chemical Engineering, Stanford University, 381 North-South Mall, Stanford, California 94305-5025, USA.

Biomacromolecules
|December 26, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Study on the association between the recovery pattern of CD4<sup>+</sup>T lymphocyte counts and the risk of death among HIV-infected individuals after antiretroviral therapy in Taizhou City, Zhejiang Province from 2006 to 2024].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2026
Same author

[Analysis of the association between CD4<sup>+</sup>T lymphocytes counts test index and immunological failure of antiretroviral therapy among HIV-infected patients in Taizhou, Zhejiang Province, from 2006 to 2024].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2026
Same author

[Current status and strategies for reoperation in thyroid cancer].

Zhonghua yi xue za zhi·2026
Same author

[A case of the "6+2" phenomenon on electrocardiogram caused by acute pulmonary embolism].

Zhonghua xin xue guan bing za zhi·2025
Same author

[Prevalence and epidemiological characteristics of major chronic diseases in people living with HIV in Taizhou, Zhejiang Province, 1998-2022].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2024
Same author

[Analysis on death causes of HIV/AIDS patients in Taizhou, Zhejiang Province, 1998-2022].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2023
Same journal

Ligno-Suberized Fruit Periderm as a Mechanically Reinforced Biomacromolecular Composite.

Biomacromolecules·2026
Same journal

Effect of Hydrophilic Brush Length and Hydrophobic Chain on Biodistribution of Polymethacrylate-Based Statistical Copolymers.

Biomacromolecules·2026
Same journal

Multicomponent Micelles with Boosted Stability of Iminoboronates.

Biomacromolecules·2026
Same journal

Stiffening and Toughening Protein Hydrogels by Tuning Electrostatic Interactions.

Biomacromolecules·2026
Same journal

<i>In Situ</i> Bulk and Interfacial Interlocking-Induced Highly Dynamically Entangled Hydrogel of Myocardium-Matching Mechanics, Electrophysiological Functions, and Robust Tissue Adhesion for Cardiac Repair.

Biomacromolecules·2026
Same journal

Eutectogel Electrodes with Self-powered Capability for Flexible Electrophysiological Sensor.

Biomacromolecules·2026
See all related articles

Researchers developed a novel method for creating stable, polymer-supported lipid membranes using lipopolymers and the Langmuir-Blodgett technique. These membranes show promising properties for biosensor applications.

Area of Science:

  • Biophysics
  • Materials Science
  • Polymer Chemistry

Background:

  • Solid-supported lipid membranes are crucial for biophysical studies and biosensor development.
  • Existing methods for creating these membranes face challenges in stability and homogeneity.

Purpose of the Study:

  • To synthesize novel lipopolymers for creating stable polymer-supported lipid membranes.
  • To investigate the self-assembly behavior and properties of these membranes on solid substrates.

Main Methods:

  • Synthesis of lipopolymers with varying alkyl side chain content.
  • Langmuir-Blodgett technique for transferring preorganized films to substrates.
  • Photochemical cross-linking for lipopolymer attachment.
  • Vesicle fusion for final membrane assembly.

Related Experiment Videos

  • Atomic force microscopy (AFM) and fluorescence microscopy for characterization.
  • Electric field analysis to determine lipid diffusion coefficients.

    • Main Results:

    • Lipopolymers with 28 mol % alkyl side chains exhibited tighter molecular packing at the air-water interface compared to those with 22 mol %.
    • Phase separation of lipopolymers was observed on hydrophobic substrates, but a mixture with free lipids formed a smooth film.
    • The distal lipid layer of the polymer-supported bilayer was homogeneous on the micrometer scale.
    • The distal lipid layer demonstrated mobility with an average diffusion coefficient of ~0.1 µm²/s, and an immobile fraction of ~15%.

    Conclusions:

    • The developed method enables the creation of homogeneous and mobile polymer-supported lipid bilayers.
    • The lipopolymer composition influences molecular packing and film formation.
    • These findings advance the development of robust solid-supported lipid membranes for advanced applications.