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Fully convergent solid phase synthesis of antifreeze glycoprotein analogues
1Department of Chemistry, State University of New York at Binghamton, Binghamton, New York 13902, USA.
Biomacromolecules
|December 26, 2001
Abstract:
The convergent solid phase synthesis of C-linked analogues of antifreeze glycoprotein (AFGP) has been achieved. In this approach, three to six carbohydrate residues are simultaneously coupled to a resin-bound polypeptide. Glycopeptides ranging from 1.6 to 3.0 kDa are easily prepared in 26-44% yield demonstrating the utility of this approach.