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Inhibition of regrowth of prostatic glandular cells by epristeride
1Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Aim:
To evaluate the ability of epristeride to inhibit the prostatic glandular regrowth.
Methods:
Normal rats were castrated. Testosterone was injected to induce the regrowth of glandular cells. HE staining was performed. The height of the glandular epithelium and the acinar luminal areas were determined, and dihydrotestosterone (DHT) was detected by immunohistochemistry.
Results:
Both the height and the acinar luminal areas were reduced by 48 % and 55 % in epristeride-treated group compared with control group respectively. The staining of DHT was comparatively strong in the control group. After 30-d of treatment, it turned much weaker.
Conclusion:
The regrowth of glandular cells was inhibited by epristeride via declining of the DHT concentration in the rat prostate.