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Related Experiment Videos

Stem cells in neurodevelopment and plasticity.

F M Vaccarino1, Y Ganat, Y Zhang

  • 1Child Study Center and Section of Neurobiology Yale University, New Haven, CT 06520, USA. Flora.vaccarino@yale.edu

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
|December 26, 2001
PubMed
Summary
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Neural stem cells in the adult central nervous system (CNS) respond differently to growth factors than during development. Transcription factors and cell interactions dictate progenitor cell fate, presenting challenges in understanding postnatal CNS development and repair.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Stem Cell Biology

Background:

  • Embryogenesis involves transcription factors regulating central nervous system (CNS) differentiation.
  • Postnatal neural stem cells may deviate from developmental sequences.
  • Growth factors like Fibroblast Growth Factor (FGF2) and Epidermal Growth Factor (EGF) influence neural progenitor cell division.

Purpose of the Study:

  • To investigate whether persistent neural stem cells in the postnatal CNS follow developmental differentiation pathways.
  • To understand the role of transcription factors and cell interactions in regulating neural progenitor cell fate in the adult CNS.
  • To explore the genetic programs controlling postnatal neural progenitor cell fate and their regulation by external factors.

Main Methods:

Related Experiment Videos

  • Comparative analysis of growth factor (FGF2) effects on neural progenitor cells during embryogenesis versus in the adult CNS.
  • Investigation of nuclear transcription factors that determine neuronal fates over time.
  • Examination of cell-cell interactions and their influence on progenitor cell proliferation and differentiation.

    • Main Results:

    • Intraventricular FGF2 administration during embryogenesis promotes cortical pyramidal neuron generation.
    • The same FGF2 treatment in the adult CNS leads to the production of olfactory bulb interneurons.
    • Neural progenitor cell responsiveness to FGF2 is modulated by nuclear transcription factors, indicating time-dependent fate constraints.

    Conclusions:

    • The fate of neural progenitor cells in the postnatal CNS is influenced by developmentally regulated transcriptional programs.
    • Cell surface interactions and environmental cues play critical roles in modulating progenitor cell behavior.
    • Understanding these genetic programs is crucial for deciphering CNS development, repair, and the impact of stress or environmental changes.