Related Experiment Video
Updated: Oct 3, 2026

A High-throughput Shigella-specific Bactericidal Assay
Published on: February 27, 2019
Enhanced anti-Shigella activity of erythromycin supplemented with sulfadiazine
1Department of Microbiology, School of Medicine, Fujita Health University, Toyoake, Aichi, Japan. yhonma@fujita-hu.ac.jp
Abstract:
Sulfadiazine enhanced the anti-Shigella activity of erythromycin. Erythromycin passes through the type III secretion apparatus and suppresses the growth of invasive Shigella organisms. Sulfadiazine enhanced this effect at the concentration under minimum inhibitory concentration and it came from not only the folate-inhibiting activity but also from a new function. It has proved that sulfadiazine stimulated type III secretion in Shigella as determined from the secretion of the pathogenic protein IpaB. As Congo red induced secretion of Ipa proteins and uptake of erythromycin through the type III secretion gate, sulfadiazine which is similar to Congo red in chemical structure may induce the uptake in the same way.
Related Concept Videos
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Bacterial Gastroenteritis
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Antiprotozoal Agents
Drugs for Treatment of Diarrhea-Predominant IBS
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...

