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Sexual dysfunction after treatment for testicular cancer: a systematic review

I Nazareth1, J Lewin, M King

  • 1Department of Primary Care and Population Sciences, Royal Free and University College London Medical School, University College London, Rowland Hill Street, London NW3 2PF, UK. i.nazareth@pcps.ucl.ac.uk

Journal of Psychosomatic Research
|December 26, 2001
PubMed
Abstract

Insights

Men treated for testicular cancer experience persistent sexual dysfunction, including reduced orgasm, erectile issues, and ejaculatory problems, for up to two years post-treatment. Further research is needed to clarify these effects.

Area of Science:

  • Oncology
  • Urology
  • Sexual Medicine

Background:

  • Testicular cancer treatment can significantly impact male reproductive health.
  • Sexual dysfunction is a common concern for survivors, affecting quality of life.

Purpose of the Study:

  • To systematically review and assess the nature and risk of sexual dysfunction in men following testicular cancer treatment.
  • To quantify the prevalence of specific sexual dysfunctions, including reduced libido, erectile dysfunction, and orgasmic/ejaculatory dysfunction.

Main Methods:

  • Systematic review of published literature on sexual dysfunction in testicular cancer patients.
  • Meta-analysis of controlled studies and analysis of uncontrolled studies to calculate odds ratios and proportions of sexual dysfunction.
  • Inclusion of data from 709 patients in controlled studies and 337 in uncontrolled studies.

Main Results:

  • Meta-analysis of controlled studies revealed significantly increased odds of reduced/absent orgasm (OR=4.62), erectile dysfunction (OR=2.47), and ejaculatory dysfunction (OR=28.57) up to 2 years post-treatment.
  • Uncontrolled studies showed less consistent effects on sexual function.
  • Limitations include low response rates, unvalidated questionnaires, and varied treatment modalities across studies.

Conclusions:

  • Sexual dysfunction, particularly concerning orgasm, erectile function, and ejaculation, persists for up to two years after testicular cancer treatment.
  • High-quality evidence is required to control for confounding factors like the cancer itself, treatment type, and psychological impact.

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