Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Galanin receptor antagonists decrease fat preference in Brattleboro rat.

M Odorizzi1, B Fernette, E Angel

  • 1Inserm U 308, 54000, Nancy, France.

Neuropharmacology
|December 26, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SU-E-I-43: Reducing Scanogram Dose Without Affecting the Planned Tube Current Modulation of a Diagnostic Abdomen/pelvis CT Scan.

Medical physics·2017
Same author

Neuropeptide Y in the Ventromedial and Suprachiasmatic Nuclei: Role in the Feeding Pattern of Monosodium Glutamate-Treated Rats.

Nutritional neuroscience·2016
Same author

Delafossite structure of heterogenite polytypes (HCoO₂) by Raman and infrared micro-spectroscopy.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2016
Same author

Fluid deprivation increases isotonic NaCl intake, but not hypertonic salt intake, under normal and heated conditions in obese Zucker rats.

Appetite·2015
Same author

Teaching a shader-based introduction to computer graphics.

IEEE computer graphics and applications·2014
Same author

Drinking water biofilm cohesiveness changes under chlorination or hydrodynamic stress.

Water research·2014
Same journal

Thyrotropin-releasing hormone and dopaminergic systems interact in the ventral tegmental area to regulate food intake in rats.

Neuropharmacology·2026
Same journal

TRPC5 as a modulator of TRPV1 signalling in pathological pain states.

Neuropharmacology·2026
Same journal

Loss of mGlu<sub>5</sub> receptors from PV inhibitory neurons attenuates sex differences in ethanol and sucrose seeking.

Neuropharmacology·2026
Same journal

PM289, a synthetic CB2 in vitro receptor agonist, modulates morphine-induced antinociceptive effect and withdrawal syndrome in an animal model of osteoarthritic pain.

Neuropharmacology·2026
Same journal

Purinergic-cytokine signaling as a regulatory axis in neuroimmune development.

Neuropharmacology·2026
Same journal

Acupuncture improves depressive symptoms and prefrontal cortical function in mild to moderate depressive disorder: A randomized sham-controlled trial and fNIRS study.

Neuropharmacology·2026
See all related articles

Researchers investigated the link between galanin (GAL) and fat consumption in Brattleboro rats. Blocking GAL receptors reduced fat intake, suggesting GAL

Area of Science:

  • Neuroscience
  • Endocrinology
  • Nutritional Science

Background:

  • Brattleboro rats exhibit a high spontaneous intake of dietary fat (46%).
  • Elevated galanin (GAL) expression in the hypothalamic paraventricular nuclei (PVN) is observed in these rats.
  • A potential functional relationship between central GAL expression and lipid diet preference is hypothesized.

Purpose of the Study:

  • To investigate the effects of GAL receptor antagonists on spontaneous fat consumption.
  • To determine the impact of these antagonists on central GAL overexpression.
  • To explore the role of GAL in regulating dietary fat preference.

Main Methods:

  • Administration of two GAL receptor antagonists (C7 and galantide) into the cerebral ventricles or PVN of Brattleboro rats.

Related Experiment Videos

  • Monitoring of diet consumption (carbohydrate, protein, fat) for 24 hours post-injection.
  • Measurement of GAL mRNA expression in the PVN.

    • Main Results:

    • C7 significantly reduced fat consumption when administered centrally or directly into the PVN.
    • Galantide reduced fat consumption only when injected directly into the PVN.
    • Neither antagonist altered GAL mRNA expression in the PVN within 2 hours of administration.

    Conclusions:

    • These findings confirm a functional link between hypothalamic GAL signaling and preferential fat consumption in Brattleboro rats.
    • The differential efficacy of the antagonists suggests the involvement of distinct GAL receptor subtypes in regulating fat intake.
    • Further research is warranted to elucidate the specific receptor subtypes mediating this effect.