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A randomised trial of progesterone prophylaxis after midtrimester amniocentesis
Francesco Corrado1, Corrado Dugo, Maria L Cannata
1Institute of Gynecology, Policlinico Universitario, 98100, Messina, Italy. f.sco_corrado@tin.it
European Journal of Obstetrics, Gynecology, and Reproductive Biology
|December 26, 2001
Abstract
Background:
Midtrimester amniocentesis to investigate fetal karyotype carries a small risk of fetal loss.
Aim:
To test the hypothesis that progesterone prophylaxis may reduce this.
Study Design:
A randomised controlled trial comparing a short prophylactic treatment with progesterone after amniocentesis with untreated controls.
Results:
There were no differences in frequency of miscarriage, preterm delivery or neonatal outcome.
Conclusion:
Prophylactic progesterone treatment after amniocentesis does not improve obstetric outcome.