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Related Experiment Videos

Rat brain expresses serum calcium-decreasing factor (caldecrin).

Akito Tomomura1, Hirotaka Yamada, Kouki Itagaki

  • 1Department of Biochemistry, Meikai University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama 350-0283, Japan. atomomu@dent.meikai.ac.jp

Neuroscience Letters
|December 26, 2001
PubMed
Summary

Caldecrin, a factor that decreases serum calcium, was found in the adult rat brain. This suggests caldecrin may play a role in central nervous system calcium homeostasis.

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Area of Science:

  • Neuroscience
  • Endocrinology
  • Biochemistry

Background:

  • Caldecrin, a serum calcium-decreasing factor cloned from the pancreas, is a chymotrypsin-type serine protease.
  • Caldecrin inhibits parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP)-induced bone resorption.

Purpose of the Study:

  • To investigate the presence and expression of caldecrin in the adult rat brain.
  • To determine the potential role of caldecrin in central nervous system calcium homeostasis.

Main Methods:

  • Western blotting to detect caldecrin protein.
  • Reverse transcription-polymerase chain reaction (RT-PCR) to detect caldecrin gene expression.
  • In situ hybridization to localize caldecrin mRNA in the brain.

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Main Results:

  • Caldecrin was detected in the adult rat brain.
  • The caldecrin gene was constitutively expressed from postnatal days 1-28.
  • Caldecrin mRNA was found throughout the brain, including the olfactory bulb, cerebrum, hippocampus, thalamus, and cerebellum.

Conclusions:

  • Caldecrin is present and expressed in the adult rat brain.
  • Caldecrin's widespread distribution in the brain suggests a potential role in central nervous system calcium regulation.