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Sequence type analysis and recombinational tests (START).
K A Jolley1, E J Feil, M S Chan
1Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK. keith.jolley@ceid.ox.ac.uk
Bioinformatics (Oxford, England)
|December 26, 2001
Summary
The START application aids bacterial population structure studies by analyzing multilocus sequence data. It offers data summary, lineage assignment, and tests for recombination and selection.
Area of Science:
- Microbiology
- Bioinformatics
- Population Genetics
Background:
- Multilocus sequence data is crucial for understanding bacterial population dynamics.
- Investigating bacterial population structure requires specialized analytical tools.
Purpose of the Study:
- To introduce the START (Sequence Typing and Analysis) application.
- To provide a tool for comprehensive analysis of bacterial population structure using multilocus sequence data.
Main Methods:
- The START application is a 32-bit Windows program developed in Visual Basic and C++.
- It processes multilocus sequence data to perform various population genetic analyses.
Main Results:
- The software facilitates data summarization and bacterial lineage assignment.
- It includes functionalities for testing recombination and selection pressures within bacterial populations.
Conclusions:
- START is a valuable resource for researchers studying bacterial population genetics.
- The application enhances the investigation of bacterial evolution and epidemiology.