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The EMBL Nucleotide Sequence Database.

Guenter Stoesser1, Wendy Baker, Alexandra van den Broek

  • 1EMBL Outstation, The European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.

Nucleic Acids Research
|December 26, 2001
PubMed
Summary
This summary is machine-generated.

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The EMBL Nucleotide Sequence Database provides organized access to public nucleotide sequences, facilitating global research through daily data exchange and web-based submission systems. It offers free network access and integrated bioinformatics tools for sequence analysis.

Area of Science:

  • Bioinformatics
  • Genomics
  • Molecular Biology Databases

Background:

  • The EMBL Nucleotide Sequence Database (EMBL-Bank) is a crucial resource for storing and distributing publicly available nucleotide sequences.
  • It operates as part of an international collaboration with DDBJ (Japan) and GenBank (USA), ensuring comprehensive data coverage.
  • The database is maintained at the European Bioinformatics Institute (EBI).

Purpose of the Study:

  • To describe the structure, data acquisition, and access methods of the EMBL Nucleotide Sequence Database.
  • To highlight the collaborative efforts and submission systems contributing to the database.
  • To outline the available bioinformatics tools and network services for accessing and analyzing sequence data.

Main Methods:

  • Data incorporation through web-based submission (Webin) and automated procedures for large-scale sequencing centers and patent offices.

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  • Daily data exchange with international collaborators (DDBJ, GenBank).
  • Quarterly database releases and continuous updates via network services (FTP, email, WWW).

    • Main Results:

    • EMBL-Bank successfully organizes and distributes a vast collection of nucleotide sequences from diverse public sources.
    • International collaboration ensures data consistency and completeness across major sequence databases.
    • Free and open access to up-to-date sequence data is provided through various network interfaces.

    Conclusions:

    • The EMBL Nucleotide Sequence Database is a vital, collaboratively maintained resource for the global scientific community.
    • Integrated bioinformatics tools, including sequence similarity search algorithms, enhance the utility of the database for research.
    • The EBI's Sequence Retrieval System (SRS) provides a unified platform for accessing and linking diverse molecular biology databases.